Abstract
The aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion.
Original language | English (US) |
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Pages (from-to) | E447-E450 |
Journal | Clinical Microbiology and Infection |
Volume | 19 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2013 |
Externally published | Yes |
Keywords
- Cervical cancer
- Human papillomavirus 18
- Molecular marker
- Physical status
- Risk assessment
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases