Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting

Song Yao, Peter T. Campbell, Tomotaka Ugai, Gretchen Gierach, Mustapha Abubakar, Viktor Adalsteinsson, Jonas Almeida, Paul Brennan, Stephen Chanock, Todd Golub, Samir Hanash, Curtis Harris, Cassandra A. Hathaway, Karl Kelsey, Maria Teresa Landi, Faisal Mahmood, Christina Newton, John Quackenbush, Scott Rodig, Nikolaus SchultzGuillermo Tearney, Shelley S. Tworoger, Molin Wang, Xuehong Zhang, Montserrat Garcia-Closas, Timothy R. Rebbeck, Christine B. Ambrosone, Shuji Ogino

Research output: Contribution to journalArticlepeer-review


Cancer heterogeneities hold the key to a deeper understanding of cancer etiology and progression and the discovery of more precise cancer therapy. Modern pathological and molecular technologies offer a powerful set of tools to profile tumor heterogeneities at multiple levels in large patient populations, from DNA to RNA, protein and epigenetics, and from tumor tissues to tumor microenvironment and liquid biopsy. When coupled with well-validated epidemiologic methodology and well-characterized epidemiologic resources, the rich tumor pathological and molecular tumor information provide new research opportunities at an unprecedented breadth and depth. This is the research space where Molecular Pathological Epidemiology (MPE) emerged over a decade ago and has been thriving since then. As a truly multidisciplinary field, MPE embraces collaborations from diverse fields including epidemiology, pathology, immunology, genetics, biostatistics, bioinformatics, and data science. Since first convened in 2013, the International MPE Meeting series has grown into a dynamic and dedicated platform for experts from these disciplines to communicate novel findings, discuss new research opportunities and challenges, build professional networks, and educate the next-generation scientists. Herein, we share the proceedings of the Fifth International MPE meeting, held virtually online, on May 24 and 25, 2021. The meeting consisted of 21 presentations organized into the three main themes, which were recent integrative MPE studies, novel cancer profiling technologies, and new statistical and data science approaches. Looking forward to the near future, the meeting attendees anticipated continuous expansion and fruition of MPE research in many research fronts, particularly immune-epidemiology, mutational signatures, liquid biopsy, and health disparities.

Original languageEnglish (US)
Pages (from-to)1107-1120
Number of pages14
JournalCancer Causes and Control
Issue number8
StatePublished - Aug 2022


  • Immuno-epidemiology
  • Meeting proceedings
  • Meeting report
  • Meeting summary
  • Molecular pathological epidemiology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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