Primary Xanthoma of the Mandible: Report of a Rare Case

Dominic Morel, Robert D. Kelsch, Patrick J. Nolan

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Xanthoma is a lesion most commonly seen in soft tissues such as the skin, subcutis, or tendon sheaths. Xanthoma formation is often associated with primary or secondary hyperlipidemia. Primary bone xanthomas are extremely rare benign bone lesions not associated with hyperlipidemia, histopathologically characterized by histiocytes, abundant lipid containing macrophages (foam cells), and multinucleated giant cells. Cholesterol clefts can be found in the medullary bone. Less than ten cases of xanthoma in the mandible have been reported. We present a rare primary intrabony xanthoma in a normolipidemic patient.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalHead and Neck Pathology
Issue number2
StatePublished - Jun 1 2016


  • Foamy histiocytes
  • Intraosseous xanthoma
  • Mandible
  • Non-Langerhans histiocytic process
  • Xanthoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology


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