Primary central nervous system lymphoma

Rebecca M. Brown, Adília Hormigo

Research output: Chapter in Book/Report/Conference proceedingChapter


Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin lymphoma affecting the brain, particularly periventricular areas, leptomeninges, spinal cord, and/or eyes. Immunocompromised patients are at greater risk than immunocompetent individuals especially patients with AIDS. Diagnosis is made through stereotactic needle biopsy. Cerebrospinal fluid analysis and victrectomy or choroidal/retinal biopsy may be sufficient to render the diagnosis. CNS staging requires evaluating the extent of disease and systemic disease must be ruled out prior to initiating treatment. Chemotherapy using a high dose HD-MTX based regimen is the first line of treatment.

Original languageEnglish (US)
Title of host publicationOncology
Number of pages12
ISBN (Electronic)9781119189596
ISBN (Print)9781119189558
StatePublished - Aug 30 2019
Externally publishedYes


  • AIDS
  • Diffuse large b-cell
  • Leptomeningeal
  • Lymphoma
  • Methotrexate
  • Ocular

ASJC Scopus subject areas

  • Medicine(all)


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