Primary adrenal leiomyosarcoma: A case report and review of the literature

Amarpreet Bhalla, Fatejeet Sandhu, Steven Sieber

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Primary adrenal leiomyosarcoma has been reported previously in 25 patients. The patient presented herein is the only case where the definitive diagnosis was made with core needle biopsy evaluation. A 45-year-old male presented with pain in the back and right groin. Radiological evaluation demonstrated a heterogeneous 11cm right adrenal mass, multiple liver masses, and an enlarged aortocaval lymph node. No retroperitoneal mass was identified. Core needle biopsies revealed a malignant mesenchymal neoplasm composed of atypical spindle shaped cells arranged in intersecting fascicles, with high mitotic activity and focal tumor necrosis. Immunohistochemical stains revealed immunoreactivity for smooth muscle actin and desmin. S-100 and c-kit stains were negative. The diagnosis of adrenal leiomyosarcoma with liver metastasis was rendered. It was an aggressive tumor with clinical presentation at an advanced stage. Definitive diagnosis of this tumor by core needle biopsy can obviate the need for surgical biopsy in patients with advanced disease.

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalConnecticut medicine
Issue number7
StatePublished - Aug 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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