Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count

M. Gandhi, D. M. Koelle, N. Ameli, P. Bacchetti, J. S. Greenspan, M. Navazesh, K. Anastos, R. M. Greenblatt

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), which occurs in epidemic form in human immunodeficiency virus(HIV)-infected individuals. Saliva is the only mucosal fluid in which infectious HHV-8 has been identified, although factors associated with HHV-8 salivary shedding remain unclear. Our study performed PCR analysis for HHV-8 DNA in saliva (and other body fluids) in 66 HIV- and HHV-8-co-infected women without KS so that we could examine predictors for HHV-8 DNA detection. CD4 count was the most significant predictor of HHV-8 salivary shedding, with increased prevalence of HHV-8 salivary DNA at higher CD4 counts. The odds of salivary HHV8 shedding at CD4 counts > = 350 cells/μL was 63 times the odds of shedding at CD4 < 350 (95%CI, 1.3-3078), with an increase in effect size when the analysis was restricted to those with a CD4 nadir > 200. Analysis of these data suggests an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention.

Original languageEnglish (US)
Pages (from-to)639-643
Number of pages5
JournalJournal of Dental Research
Issue number8
StatePublished - Aug 2004
Externally publishedYes


  • CD4 count
  • HHV-8
  • HIV
  • Kaposi's sarcoma
  • Salivary shedding

ASJC Scopus subject areas

  • General Dentistry


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