TY - JOUR
T1 - Prevalence and cumulative incidence of and risk factors for anemia in a multicenter cohort study of human immunodeficiency virus-infected and -uninfected women
AU - Semba, Richard D.
AU - Klein, Robert S.
AU - Mayer, Kenneth H.
AU - Schuman, Paula
AU - Vlahov, David
AU - Klein, Robert S.
AU - Schoenbaum, Ellie
AU - Arnsten, Julie
AU - Burk, Robert D.
AU - Chang, Chee Jen
AU - Demas, Penelope
AU - Howard, Andrea
AU - Schuman, Paula
AU - Sobel, Jack
AU - Rompalo, Anne
AU - Vlahov, David
AU - Celentano, David
AU - Shah, Nina
AU - Carpenter, Charles
AU - Mayer, Kenneth
AU - Cu-Uvin, Susan
AU - Flanigan, Timothy
AU - Hogan, Joseph
AU - Stone, Valerie
AU - Tashima, Karen
AU - Rich, Josiah
AU - Duerr, Ann
AU - Gardner, Lytt I.
AU - Heilig, Chad
AU - Holmberg, Scott D.
AU - Jamieson, Denise J.
AU - Moore, Janet S.
AU - Phelps, Ruby M.
AU - Smith, Dawn K.
AU - Warren, Dora
AU - Davenny, Katherine
N1 - Funding Information:
Financial support: National Institute on Drug Abuse (grants DA10252, DA04334, and DA08009), National Institute for Allergy and Infectious Diseases (grant AI41956), and Cooperative Agreements (U64 CU106795, U64 CU200798, U64 CU306802, and U64 CU506831) with the US Centers for Disease Control and Prevention.
PY - 2002/1/15
Y1 - 2002/1/15
N2 - We conducted a longitudinal study of 797 human immunodeficiency virus (HIV)-positive women (7732 visits) and 389 HIV-negative women (3651 visits) to characterize anemia. At enrollment, the prevalence of anemia was 28.1% among HIV-positive women and 15.1% among HIV-negative women (P<.0001), and during follow-up the cumulative incidence of anemia was 74% and 48%, respectively (P<.0001). Risk factors for anemia were African American race (odds ratio [OR], 2.15; 95% confidence interval [CI], 1.73-2.69), age (per 5-year increase; OR, 1.12; 95% CI, 1.03-1.21), body mass index (OR, 0.96; 95% CI, 0.94-0.97), history of pneumonia (OR, 1.41; 95% CI, 1.20-1.65), oral candidiasis (OR, 1.42; 95% CI, 1.22-1.66), CD4+ lymphocyte count <200 cells/μL (OR, 1.68; 95% CI, 1.46-1.94), history of fever (OR, 1.42; 95% CI, 1.13-1.80), and zidovudine use (OR, 1.14; 95% CI, 1.01-1.30). Anemia was common and associated with an increased risk of death (hazards ratio, 1.64; 95% CI, 1.21-2.23) among HIV-positive women.
AB - We conducted a longitudinal study of 797 human immunodeficiency virus (HIV)-positive women (7732 visits) and 389 HIV-negative women (3651 visits) to characterize anemia. At enrollment, the prevalence of anemia was 28.1% among HIV-positive women and 15.1% among HIV-negative women (P<.0001), and during follow-up the cumulative incidence of anemia was 74% and 48%, respectively (P<.0001). Risk factors for anemia were African American race (odds ratio [OR], 2.15; 95% confidence interval [CI], 1.73-2.69), age (per 5-year increase; OR, 1.12; 95% CI, 1.03-1.21), body mass index (OR, 0.96; 95% CI, 0.94-0.97), history of pneumonia (OR, 1.41; 95% CI, 1.20-1.65), oral candidiasis (OR, 1.42; 95% CI, 1.22-1.66), CD4+ lymphocyte count <200 cells/μL (OR, 1.68; 95% CI, 1.46-1.94), history of fever (OR, 1.42; 95% CI, 1.13-1.80), and zidovudine use (OR, 1.14; 95% CI, 1.01-1.30). Anemia was common and associated with an increased risk of death (hazards ratio, 1.64; 95% CI, 1.21-2.23) among HIV-positive women.
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U2 - 10.1086/338151
DO - 10.1086/338151
M3 - Article
C2 - 11740716
AN - SCOPUS:0037079841
SN - 1058-4838
VL - 34
SP - 260
EP - 266
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 2
ER -
