TY - JOUR
T1 - Prevalence and correlates of anemia in a large cohort of HIV-infected women
T2 - Women's interagency hiv study
AU - Levine, Alexandra M.
AU - Berhane, Kiros
AU - Masri-Lavine, Lena
AU - Sanchez, Maria Lynn
AU - Young, Mary
AU - Augenbraun, Michael
AU - Cohen, Mardge
AU - Anastos, Kathryn
AU - Newman, Margaret
AU - Gange, Stephen J.
AU - Watts, Heather
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Anemia is a common manifestation of HIV infection, occurring in approximately 30% of patients with asymptomatic infection and in as many as 75% to 80% of those with AIDS. Anemia has been associated with decreased quality of life and decreased survival. We performed a cross-sectional study nested within a multicenter prospective cohort study to describe the prevalence of anemia in 2056 HIV-infected and 569 HIV-negative women as well as to define the demographic, clinical, immunologic, and virologic correlates of anemia among HIV-infected women. A total of 37% of HIV-positive women and 17% of HIV-negative women had hemoglobin levels < 12 g/dl (p < .001). Factors associated with anemia in HIV-positive and HIV-negative women included mean corpuscular volume (MCV) < 80 fl (p < .001) and black race (p < .001). Among HIV-infected women, multivariate logistic analyses revealed that African American race (p < .0001), MCV < 80 fl (p < .0001), CD4 count < 200 per microliter (p < .0001), higher HIV RNA in plasma (p = .02), current use of ZDV (p = .01), and history of clinical AIDS (p = .004) were all independent predictors of anemia. These data indicate that worsening parameters of HIV disease are associated with anemia among HIV-infected women. Black women and women with low MCV values are at increased risk for anemia independent of HIV status.
AB - Anemia is a common manifestation of HIV infection, occurring in approximately 30% of patients with asymptomatic infection and in as many as 75% to 80% of those with AIDS. Anemia has been associated with decreased quality of life and decreased survival. We performed a cross-sectional study nested within a multicenter prospective cohort study to describe the prevalence of anemia in 2056 HIV-infected and 569 HIV-negative women as well as to define the demographic, clinical, immunologic, and virologic correlates of anemia among HIV-infected women. A total of 37% of HIV-positive women and 17% of HIV-negative women had hemoglobin levels < 12 g/dl (p < .001). Factors associated with anemia in HIV-positive and HIV-negative women included mean corpuscular volume (MCV) < 80 fl (p < .001) and black race (p < .001). Among HIV-infected women, multivariate logistic analyses revealed that African American race (p < .0001), MCV < 80 fl (p < .0001), CD4 count < 200 per microliter (p < .0001), higher HIV RNA in plasma (p = .02), current use of ZDV (p = .01), and history of clinical AIDS (p = .004) were all independent predictors of anemia. These data indicate that worsening parameters of HIV disease are associated with anemia among HIV-infected women. Black women and women with low MCV values are at increased risk for anemia independent of HIV status.
KW - Anemia
KW - HIV
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=0035146644&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035146644&partnerID=8YFLogxK
U2 - 10.1097/00042560-200101010-00004
DO - 10.1097/00042560-200101010-00004
M3 - Article
C2 - 11176266
AN - SCOPUS:0035146644
SN - 1525-4135
VL - 26
SP - 28
EP - 35
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 1
ER -