Prenatal exposure to aspartame and seizure susceptibility

Ellen F. Sperber, Solomon L. Moshé, Diana L. Dow-Edwards

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Aspartame has been reported to be proconvulsant in rats and mice. To determine whether gestational exposure to aspartame alters susceptibility to flurothyl-induced seizures in offspring, we administered either 500 or 750 mg/kg aspartame to pregnant guinea pigs throughout pregnancy. The offspring were exposed to flurothyl at age 30 days to determine the threshold for clonic and tonic seizures. We also examined offspring from a gavaged control group and a nontreated control group. There were no statistically significant differences in either clonic or tonic seizure thresholds among all groups. Therefore, aspartame administration throughout pregnancy in guinea pigs had no epileptogenic potential in the flurothyl model.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalJournal of Epilepsy
Issue number1
StatePublished - 1995


  • Artificial sweetners
  • Aspartame
  • Development
  • Guinea pigs
  • Phenylalanine
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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