Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver

I. Azorin; F. Lazaro; J. M. Martinez; M. Portoles; C. Guerri; J. Renau-Piqueras

Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver

I. Azorin, F. Lazaro, J. M. Martinez, M. Portoles, C. Guerri, J. Renau-Piqueras

Research output: Contribution to journal › Article › peer-review

Abstract

Prenatal alcohol exposure alters the liver and induces pathological changes in the morphology and function of the Golgi apparatus (GA), including an accumulation or reduced transport of newly synthesized glycoconjugates which suggests that ethanol could affect the cytoskeleton (CSK) in hepatocytes. To test this possibility we have analysed, using various techniques, the effect of ethanol "in utero" on several CSK proteins including actin, α- tubulin, cytokeratin, vimentin and the motor associated proteins dynein and kinesin. Our results show that this treatment increases the amount of both α-tubulin and cytokeratin and alters its distribution.

Original language	English (US)
Pages (from-to)	S151-S152
Journal	International Journal of Developmental Biology
Volume	45
Issue number	SUPPL. 1
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Embryology
Developmental Biology

Cite this

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T1 - Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver

AU - Azorin, I.

AU - Lazaro, F.

AU - Martinez, J. M.

AU - Portoles, M.

AU - Guerri, C.

AU - Renau-Piqueras, J.

PY - 2001

Y1 - 2001

N2 - Prenatal alcohol exposure alters the liver and induces pathological changes in the morphology and function of the Golgi apparatus (GA), including an accumulation or reduced transport of newly synthesized glycoconjugates which suggests that ethanol could affect the cytoskeleton (CSK) in hepatocytes. To test this possibility we have analysed, using various techniques, the effect of ethanol "in utero" on several CSK proteins including actin, α- tubulin, cytokeratin, vimentin and the motor associated proteins dynein and kinesin. Our results show that this treatment increases the amount of both α-tubulin and cytokeratin and alters its distribution.

AB - Prenatal alcohol exposure alters the liver and induces pathological changes in the morphology and function of the Golgi apparatus (GA), including an accumulation or reduced transport of newly synthesized glycoconjugates which suggests that ethanol could affect the cytoskeleton (CSK) in hepatocytes. To test this possibility we have analysed, using various techniques, the effect of ethanol "in utero" on several CSK proteins including actin, α- tubulin, cytokeratin, vimentin and the motor associated proteins dynein and kinesin. Our results show that this treatment increases the amount of both α-tubulin and cytokeratin and alters its distribution.

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ER -

Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver

Abstract

ASJC Scopus subject areas

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