Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7

Bibiana Bielekova; Paolo A. Muraro; Ladan Golestaneh; Jeanick Pascal; Henry F. McFarland; Roland Martin

doi:10.1016/S0165-5728(99)00200-3

Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7

Bibiana Bielekova, Paolo A. Muraro, Ladan Golestaneh, Jeanick Pascal, Henry F. McFarland, Roland Martin

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

We have developed a new technique that allows us to quantify antigen-specific T cells, and to determine their functional phenotype and origin from naive versus memory populations. Using this methodology, we have characterized a total of 286 T-cell lines specific for myelin basic protein (MBP) and influenza hemagglutinin from 16 multiple sclerosis (MS) patients and nine healthy donors. Our data support the notion that MBP-specific T cells undergo in vivo activation in MS patients and indicate a presence of immune dysregulation that renders MS patients prone to develop autoimmunity. Our methodology offers a way to study antigen-specific T-cell characteristics as a surrogate marker in immunotherapy trials. Copyright (C) 1999 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	115-123
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	100
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(99)00200-3
State	Published - Dec 1999
Externally published	Yes

Keywords

Antigen-specific T cells
Interleukin-7
Multiple sclerosis
Primary proliferation

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(99)00200-3

Cite this

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abstract = "We have developed a new technique that allows us to quantify antigen-specific T cells, and to determine their functional phenotype and origin from naive versus memory populations. Using this methodology, we have characterized a total of 286 T-cell lines specific for myelin basic protein (MBP) and influenza hemagglutinin from 16 multiple sclerosis (MS) patients and nine healthy donors. Our data support the notion that MBP-specific T cells undergo in vivo activation in MS patients and indicate a presence of immune dysregulation that renders MS patients prone to develop autoimmunity. Our methodology offers a way to study antigen-specific T-cell characteristics as a surrogate marker in immunotherapy trials. Copyright (C) 1999 Elsevier Science B.V.",

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AU - Bielekova, Bibiana

AU - Muraro, Paolo A.

AU - Golestaneh, Ladan

AU - Pascal, Jeanick

AU - McFarland, Henry F.

AU - Martin, Roland

PY - 1999/12

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Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7

Abstract

Keywords

ASJC Scopus subject areas

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