Predictors of hypomania during ventral capsule/ventral striatum deep brain stimulation

Alik S. Widge, Ernesto Licon, Samuel Zorowitz, Andrew Corse, Amanda R. Arulpragasam, Joan A. Camprodon, Cristina Cusin, Emad N. Eskandar, Thilo Deckersbach, Darin D. Dougherty

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact. It was more common with right monopolar stimulation. These findings may help to establish decision rules to reduce complications of VC/VS DBS.

Original languageEnglish (US)
Pages (from-to)38-44
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
StatePublished - Dec 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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