Predicting and Understanding the Human Microbiome's Impact on Pharmacology

Our bodies each possess a unique and dynamic collection of microbes and viruses, collectively the ‘microbiome’, with distinct metabolic capacities from our human cells. Unforeseen modification of drugs by the microbiome can drastically alter their clinical effectiveness, with the most dramatic cases leading to fatal drug interactions. Pharmaceuticals can be activated, deactivated, toxified, or release metabolites that alter the ‘canonical’ pharmacokinetics of the drug. Thus, predicting and characterizing microbe–drug interactions is necessary to develop and implement personalized drug administration protocols and, more broadly, to improve drug safety and efficacy. In this review, we focus on microbiome-driven alterations to drug pharmacokinetics and provide a research framework for pharmacologists interested in characterizing microbiome interactions with any drug of interest.