Preclinical mouse models for cancer chemoprevention studies

Martin Lipkin, Kan Yang, Winfried Edelmann, Xue Lexun, Fan Kunhua, Mauro Risio, Harold Newmark, Raju Kucherlapati

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


To aid in identifying the ability of chemopreventive agents to inhibit tumor development, new preclinical in vivo rodent models have recently been developed. Some of the models contain targeted mutations capable of increasing the incidence and progression of neoplastic lesions, whereas in other models dietary nutrients induce preneoplastic lesions in normal mice. These new preclinical models are assisting the analysis of genetic and environmental factors leading to neoplasia, and clinical studies to evaluate the chemopreventive efficacy of specific nutrients and pharmacological agents.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalAnnals of the New York Academy of Sciences
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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