Pre-hospital frailty and hospital outcomes in adults with acute respiratory failure requiring mechanical ventilation

Aluko A. Hope, Oriade Adeoye, Elizabeth H. Chuang, S. J. Hsieh, Hayley B. Gershengorn, Michelle N. Gong

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Purpose: We aimed to estimate the independent effect of pre-hospital frailty (PHF) on hospital mortality and prolonged hospital length of stay (pLOS) while adjusting for other patient level factors. Methods: This is a cohort study of hospitalized adults with acute respiratory failure (ARF) who required invasive mechanical ventilation for ≥ 24 h in 2013. We used inpatient/outpatient claims from a list of diagnoses from the year before index hospital admission to define PHF. Differences in characteristics/outcomes by PHF were explored using descriptive statistics; multivariable logistic regression was used to estimate association between PHF and hospital outcomes. Results: Among 1157 patients (mean age (standard deviation) 67.1 [16.4]), 53.2% had PHF. PHF was independently associated with higher hospital mortality (44.2% in PHF patients vs. 34.6% in those without, adjusted Odds Ratio (aOR) (95% Confidence Interval [CI] 1.56 (1.19–2.05), p < 0.001). PHF was also significantly associated with pLOS in hospital survivors (55.5% PHF patients had pLOS versus 34.2% in those without, aOR (95% CI) 2.61 (1.87–3.65), p < 0.001). Conclusions: PHF, identified by frailty diagnoses from before index hospitalization, may be a useful approach for identifying adults with ARF at increased risk of hospital mortality and pLOS.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalJournal of Critical Care
StatePublished - Apr 2018


  • Acute respiratory failure
  • Frailty
  • Hospital length-of-stay
  • Hospital mortality

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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