Abstract
Protein disulphide isomerase (PDI) family members are predominantly endoplasmic reticulum (ER)-bound chaperonic proteins, which have also been shown to be present on the cell surface. Some of them have been found to be associated with lipid rafts, MHC class I, and cell-signaling molecules such as signal transducer and activator of transcription (STAT) proteins in certain viral infections. Since there is evidence suggesting that PDIs have a role in the virus entry to the cell, they obviously play an important role in virus-host interactions and viral pathogenesis. In this review, we discuss potential roles of PDIs in viral infections, in order to disclose new antiviral therapeutic targets.
Original language | English (US) |
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Pages (from-to) | 293-304 |
Number of pages | 12 |
Journal | Acta Virologica |
Volume | 57 |
Issue number | 3 |
DOIs | |
State | Published - 2013 |
Externally published | Yes |
Keywords
- Chaperone
- Protein disulphide isomerase
- Virus
ASJC Scopus subject areas
- Virology
- Infectious Diseases