TY - JOUR
T1 - Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people
AU - Meza-Miranda, Eliana Romina
AU - Camargo, Antonio
AU - Rangel-Zuñiga, Oriol Alberto
AU - Delgado-Lista, Javier
AU - Garcia-Rios, Antonio
AU - Perez-Martinez, Pablo
AU - Tasset-Cuevas, Inma
AU - Tunez, Isaac
AU - Tinahones, Francisco J.
AU - Perez-Jimenez, Francisco
AU - Lopez-Miranda, José
N1 - Funding Information:
Acknowledgments The CIBEROBN is an initiative of the Instituto de Salud Carlos III, Madrid, Spain. We thank Maria Jose Gomez-Luna for technical support. This study was supported in part by research grants from the Spanish Ministry of Science and Innovation (AGL2004-07907, AGL2006-01979, and AGL2009-12270 to J L-M; SAF07-62005 and PI10/02412 to F P-J; and FIS PI10/01041 to P P-M); Consejería de Economía, Innovación y Ciencia, Proyectos de Investigación de Excelencia, Junta de Andalucía (P06-CTS-01425 to J L-M; CTS5015 and AGR922 to F P-J); Consejería de Salud, Junta de Andalucía (06/128, 07/43, and PI0193/09 to J L-M; 06/129 to F P-J; 0118/08 to F F-J; PI-0252/09 to J D-L; and PI-0058/10 to P P-M); Fondo Europeo de Desarrollo Regional.
PY - 2014/4
Y1 - 2014/4
N2 - We have investigated whether dietary fat modifies the postprandial oxidative stress in adipose tissue of elderly people. Twenty participants received three diets for 4 weeks each: SFA-rich diet, Mediterranean (Med) diet enriched in MUFA with virgin olive oil, and a low-fat, high-carbohydrate diet enriched in n-3 PUFA (α-linolenic acid from plant origin) (CHO-PUFA diet). After 12 h of fasting, volunteers received a breakfast reflecting the fatty acid composition of the diet ingested in the preceding dietary period. Med diet induced higher postprandial SOD2 and TrxR mRNA levels, and CHO-PUFA diet induced higher GPx1 and TrxR mRNA levels compared with SFA-rich diet. Med and CHO-PUFA breakfasts induced a postprandial increase in plasma reduced glutathione (GSH), and a greater postprandial GSH/oxidized glutathione ratio compared to the SFA-rich diet. Our study suggests that the consumption of Med and CHO-PUFA diets may reduce postprandial oxidative stress compared to an SFA-rich diet, which may be due to higher antioxidant enzymes gene expression in adipose tissue.
AB - We have investigated whether dietary fat modifies the postprandial oxidative stress in adipose tissue of elderly people. Twenty participants received three diets for 4 weeks each: SFA-rich diet, Mediterranean (Med) diet enriched in MUFA with virgin olive oil, and a low-fat, high-carbohydrate diet enriched in n-3 PUFA (α-linolenic acid from plant origin) (CHO-PUFA diet). After 12 h of fasting, volunteers received a breakfast reflecting the fatty acid composition of the diet ingested in the preceding dietary period. Med diet induced higher postprandial SOD2 and TrxR mRNA levels, and CHO-PUFA diet induced higher GPx1 and TrxR mRNA levels compared with SFA-rich diet. Med and CHO-PUFA breakfasts induced a postprandial increase in plasma reduced glutathione (GSH), and a greater postprandial GSH/oxidized glutathione ratio compared to the SFA-rich diet. Our study suggests that the consumption of Med and CHO-PUFA diets may reduce postprandial oxidative stress compared to an SFA-rich diet, which may be due to higher antioxidant enzymes gene expression in adipose tissue.
KW - Aging
KW - Dietary fat
KW - Metabolic syndrome
KW - Oxidative stress
KW - Postprandial state
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U2 - 10.1007/s11357-013-9579-y
DO - 10.1007/s11357-013-9579-y
M3 - Article
C2 - 23963800
AN - SCOPUS:84898870398
SN - 0161-9152
VL - 36
SP - 507
EP - 517
JO - AGE
JF - AGE
IS - 2
ER -