Possible effect of maternal promethazine therapy on neonatal immunologic functions

Arye Rubinstein; Arthur I. Eidelman; Julian Melamed; Lawrence M. Gartner; Stephen Kandall; Harold Schulman

doi:10.1016/S0022-3476(76)80950-X

Possible effect of maternal promethazine therapy on neonatal immunologic functions

Arye Rubinstein, Arthur I. Eidelman, Julian Melamed, Lawrence M. Gartner, Stephen Kandall, Harold Schulman

Pediatrics

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.

Original language	English (US)
Pages (from-to)	136-138
Number of pages	3
Journal	The Journal of Pediatrics
Volume	89
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(76)80950-X
State	Published - Jul 1976

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(76)80950-X

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abstract = "The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.",

author = "Arye Rubinstein and Eidelman, {Arthur I.} and Julian Melamed and Gartner, {Lawrence M.} and Stephen Kandall and Harold Schulman",

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AU - Rubinstein, Arye

AU - Eidelman, Arthur I.

AU - Melamed, Julian

AU - Gartner, Lawrence M.

AU - Kandall, Stephen

AU - Schulman, Harold

PY - 1976/7

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N2 - The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.

AB - The effect of the administration of promethazine in the treatment of erythroblastosis fetalis was studied in four maternal-fetal pairs. The three infants exposed for a prolonged period of time had decreased neonatal number and function of T cells, and abnormal specific humoral immune responses. The possible role of promethazine in the induction of fetal immunoincompetence is discussed.

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Possible effect of maternal promethazine therapy on neonatal immunologic functions

Abstract

ASJC Scopus subject areas

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