TY - JOUR
T1 - Population simulation modeling of disparities in US breast cancer mortality
AU - Mandelblatt, Jeanne S.
AU - Schechter, Clyde B.
AU - Stout, Natasha K.
AU - Huang, Hui
AU - Stein, Sarah
AU - Hunter Chapman, Christina
AU - Trentham-Dietz, Amy
AU - Jayasekera, Jinani
AU - Gangnon, Ronald E.
AU - Hampton, John M.
AU - Abraham, Linn
AU - O’Meara, Ellen S.
AU - Sheppard, Vanessa B.
AU - Lee, Sandra J.
N1 - Publisher Copyright:
© 2023 Oxford University Press. All rights reserved.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Background: Populations of African American or Black women have persistently higher breast cancer mortality than the overall US population, despite having slightly lower age-adjusted incidence. Methods: Three Cancer Intervention and Surveillance Modeling Network simulation teams modeled cancer mortality disparities between Black female populations and the overall US population. Model inputs used racial group–specific data from clinical trials, national registries, nationally representative surveys, and observational studies. Analyses began with cancer mortality in the overall population and sequentially replaced parameters for Black populations to quantify the percentage of modeled breast cancer morality disparities attributable to differences in demographics, incidence, access to screening and treatment, and variation in tumor biology and response to therapy. Results: Results were similar across the 3 models. In 2019, racial differences in incidence and competing mortality accounted for a net –1% of mortality disparities, while tumor subtype and stage distributions accounted for a mean of 20% (range across models ¼ 13%-24%), and screening accounted for a mean of 3% (range ¼ 3%-4%) of the modeled mortality disparities. Treatment parameters accounted for the majority of modeled mortality disparities: mean ¼ 17% (range ¼ 16%-19%) for treatment initiation and mean ¼ 61% (range ¼ 57%-63%) for real-world effectiveness. Conclusion: Our model results suggest that changes in policies that target improvements in treatment access could increase breast cancer equity. The findings also highlight that efforts must extend beyond policies targeting equity in treatment initiation to include high-quality treatment completion. This research will facilitate future modeling to test the effects of different specific policy changes on mortality disparities.
AB - Background: Populations of African American or Black women have persistently higher breast cancer mortality than the overall US population, despite having slightly lower age-adjusted incidence. Methods: Three Cancer Intervention and Surveillance Modeling Network simulation teams modeled cancer mortality disparities between Black female populations and the overall US population. Model inputs used racial group–specific data from clinical trials, national registries, nationally representative surveys, and observational studies. Analyses began with cancer mortality in the overall population and sequentially replaced parameters for Black populations to quantify the percentage of modeled breast cancer morality disparities attributable to differences in demographics, incidence, access to screening and treatment, and variation in tumor biology and response to therapy. Results: Results were similar across the 3 models. In 2019, racial differences in incidence and competing mortality accounted for a net –1% of mortality disparities, while tumor subtype and stage distributions accounted for a mean of 20% (range across models ¼ 13%-24%), and screening accounted for a mean of 3% (range ¼ 3%-4%) of the modeled mortality disparities. Treatment parameters accounted for the majority of modeled mortality disparities: mean ¼ 17% (range ¼ 16%-19%) for treatment initiation and mean ¼ 61% (range ¼ 57%-63%) for real-world effectiveness. Conclusion: Our model results suggest that changes in policies that target improvements in treatment access could increase breast cancer equity. The findings also highlight that efforts must extend beyond policies targeting equity in treatment initiation to include high-quality treatment completion. This research will facilitate future modeling to test the effects of different specific policy changes on mortality disparities.
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U2 - 10.1093/jncimonographs/lgad023
DO - 10.1093/jncimonographs/lgad023
M3 - Article
C2 - 37947337
AN - SCOPUS:85176397894
SN - 1052-6773
VL - 2023
SP - 178
EP - 187
JO - NCI Monographs
JF - NCI Monographs
IS - 62
ER -