TY - JOUR
T1 - Pombe Cdc15 homology (PCH) proteins
T2 - coordinators of membrane-cytoskeletal interactions
AU - Chitu, Violeta
AU - Stanley, E. Richard
N1 - Funding Information:
We thank Yee-Guide Yeung and Andreea Radulescu for critically reading the manuscript. The authors’ work was supported by a Susan G. Komen Breast Cancer Foundation Postdoctoral Fellowship PDF0201811 (to V.C.), National Institutes of Health grants (RO1s CA25604, CA32331 and PO1 CA100324) (to E.R.S.) and by the Albert Einstein College of Medicine Cancer Center (P30 CA13330).
PY - 2007/3
Y1 - 2007/3
N2 - Cellular adhesion, motility, endocytosis, exocytosis and cytokinesis involve the coordinated reorganization of the cytoskeleton and of the plasma membrane. The 'Pombe Cdc15 homology' (PCH) family of adaptor proteins has recently been shown to coordinate the membrane and cytoskeletal dynamics involved in these processes by curving membranes, recruiting dynamin and controlling the architecture of the actin cytoskeleton. Mutations in PCH family members or proteins that interact with them are associated with autoinflammatory, neurological or neoplastic diseases. Here, we review the nature, actions and disease associations of the vertebrate PCH family members, highlighting their fundamental roles in the regulation of processes involving membrane-cytoskeletal interactions.
AB - Cellular adhesion, motility, endocytosis, exocytosis and cytokinesis involve the coordinated reorganization of the cytoskeleton and of the plasma membrane. The 'Pombe Cdc15 homology' (PCH) family of adaptor proteins has recently been shown to coordinate the membrane and cytoskeletal dynamics involved in these processes by curving membranes, recruiting dynamin and controlling the architecture of the actin cytoskeleton. Mutations in PCH family members or proteins that interact with them are associated with autoinflammatory, neurological or neoplastic diseases. Here, we review the nature, actions and disease associations of the vertebrate PCH family members, highlighting their fundamental roles in the regulation of processes involving membrane-cytoskeletal interactions.
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U2 - 10.1016/j.tcb.2007.01.003
DO - 10.1016/j.tcb.2007.01.003
M3 - Review article
C2 - 17296299
AN - SCOPUS:33847343505
SN - 0962-8924
VL - 17
SP - 145
EP - 156
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 3
ER -