Polymorphisms in integrin genes and lymphoma risk

Min Shen; Tongzhang Zheng; Qing Lan; Yawei Zhang; H. Dean Hosgood; Shelia H. Zahm; Theodore R. Holford; Brian Leaderer; Meredith Yeager; Jeff Yuenger; Stephen Chanock; Nathaniel Rothman

doi:10.1016/j.leukres.2010.12.012

Polymorphisms in integrin genes and lymphoma risk

Min Shen, Tongzhang Zheng, Qing Lan, Yawei Zhang, H. Dean Hosgood, Shelia H. Zahm, Theodore R. Holford, Brian Leaderer, Meredith Yeager, Jeff Yuenger, Stephen Chanock, Nathaniel Rothman

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Immune deficiency is one of the best characterized and strongest known risk factors for non-Hodgkin lymphoma (NHL). We studied the association between single nucleotide polymorphisms (SNPs) in integrin genes that are important components in human innate immunity and the risk of NHL in a population-based case-control study of women in Connecticut, USA. A total of 373 tag SNPs in 33 gene regions were included in the analysis of 448 cases and 525 controls. The ADAM19 rs11466782 SNP was associated with an increased risk of lymphoma (OR, 1.73; 95% CI, 1.28-2.35; P_additive=0.0004), and the ICAM3 rs2304240 (OR, 0.67; 95% CI, 0.52-0.86; P_additive=0.002) and the PTGDR rs708486 SNPs (OR, 0.75; 95% CI, 0.63-0.90; P_additive=0.002) were associated with reduced risk of lymphoma. Two gene regions (ADAM19 (P=0.009) and ICAM3 (P=0.009)) displayed global associations with lymphoma risk at the P<0.01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations.

Original language	English (US)
Pages (from-to)	968-970
Number of pages	3
Journal	Leukemia Research
Volume	35
Issue number	7
DOIs	https://doi.org/10.1016/j.leukres.2010.12.012
State	Published - Jul 2011
Externally published	Yes

Keywords

Innate immunity
Integrin
Lymphoma
Single nucleotide polymorphism

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2010.12.012

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@article{531f51473d4d476784bf565b06d22228,

title = "Polymorphisms in integrin genes and lymphoma risk",

abstract = "Immune deficiency is one of the best characterized and strongest known risk factors for non-Hodgkin lymphoma (NHL). We studied the association between single nucleotide polymorphisms (SNPs) in integrin genes that are important components in human innate immunity and the risk of NHL in a population-based case-control study of women in Connecticut, USA. A total of 373 tag SNPs in 33 gene regions were included in the analysis of 448 cases and 525 controls. The ADAM19 rs11466782 SNP was associated with an increased risk of lymphoma (OR, 1.73; 95% CI, 1.28-2.35; Padditive=0.0004), and the ICAM3 rs2304240 (OR, 0.67; 95% CI, 0.52-0.86; Padditive=0.002) and the PTGDR rs708486 SNPs (OR, 0.75; 95% CI, 0.63-0.90; Padditive=0.002) were associated with reduced risk of lymphoma. Two gene regions (ADAM19 (P=0.009) and ICAM3 (P=0.009)) displayed global associations with lymphoma risk at the P<0.01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations.",

keywords = "Innate immunity, Integrin, Lymphoma, Single nucleotide polymorphism",

author = "Min Shen and Tongzhang Zheng and Qing Lan and Yawei Zhang and Hosgood, {H. Dean} and Zahm, {Shelia H.} and Holford, {Theodore R.} and Brian Leaderer and Meredith Yeager and Jeff Yuenger and Stephen Chanock and Nathaniel Rothman",

note = "Funding Information: This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health , under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Support for this study was also provided by the NIH grant CA62006 (T.Z). ",

year = "2011",

month = jul,

doi = "10.1016/j.leukres.2010.12.012",

language = "English (US)",

volume = "35",

pages = "968--970",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "7",

}

TY - JOUR

T1 - Polymorphisms in integrin genes and lymphoma risk

AU - Shen, Min

AU - Zheng, Tongzhang

AU - Lan, Qing

AU - Zhang, Yawei

AU - Hosgood, H. Dean

AU - Zahm, Shelia H.

AU - Holford, Theodore R.

AU - Leaderer, Brian

AU - Yeager, Meredith

AU - Yuenger, Jeff

AU - Chanock, Stephen

AU - Rothman, Nathaniel

N1 - Funding Information: This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health , under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Support for this study was also provided by the NIH grant CA62006 (T.Z).

PY - 2011/7

Y1 - 2011/7

N2 - Immune deficiency is one of the best characterized and strongest known risk factors for non-Hodgkin lymphoma (NHL). We studied the association between single nucleotide polymorphisms (SNPs) in integrin genes that are important components in human innate immunity and the risk of NHL in a population-based case-control study of women in Connecticut, USA. A total of 373 tag SNPs in 33 gene regions were included in the analysis of 448 cases and 525 controls. The ADAM19 rs11466782 SNP was associated with an increased risk of lymphoma (OR, 1.73; 95% CI, 1.28-2.35; Padditive=0.0004), and the ICAM3 rs2304240 (OR, 0.67; 95% CI, 0.52-0.86; Padditive=0.002) and the PTGDR rs708486 SNPs (OR, 0.75; 95% CI, 0.63-0.90; Padditive=0.002) were associated with reduced risk of lymphoma. Two gene regions (ADAM19 (P=0.009) and ICAM3 (P=0.009)) displayed global associations with lymphoma risk at the P<0.01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations.

AB - Immune deficiency is one of the best characterized and strongest known risk factors for non-Hodgkin lymphoma (NHL). We studied the association between single nucleotide polymorphisms (SNPs) in integrin genes that are important components in human innate immunity and the risk of NHL in a population-based case-control study of women in Connecticut, USA. A total of 373 tag SNPs in 33 gene regions were included in the analysis of 448 cases and 525 controls. The ADAM19 rs11466782 SNP was associated with an increased risk of lymphoma (OR, 1.73; 95% CI, 1.28-2.35; Padditive=0.0004), and the ICAM3 rs2304240 (OR, 0.67; 95% CI, 0.52-0.86; Padditive=0.002) and the PTGDR rs708486 SNPs (OR, 0.75; 95% CI, 0.63-0.90; Padditive=0.002) were associated with reduced risk of lymphoma. Two gene regions (ADAM19 (P=0.009) and ICAM3 (P=0.009)) displayed global associations with lymphoma risk at the P<0.01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations.

KW - Innate immunity

KW - Integrin

KW - Lymphoma

KW - Single nucleotide polymorphism

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UR - http://www.scopus.com/inward/citedby.url?scp=79958739572&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2010.12.012

DO - 10.1016/j.leukres.2010.12.012

M3 - Article

C2 - 21239057

AN - SCOPUS:79958739572

SN - 0145-2126

VL - 35

SP - 968

EP - 970

JO - Leukemia Research

JF - Leukemia Research

IS - 7

ER -

Polymorphisms in integrin genes and lymphoma risk

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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