Plasmodium falciparum: Inhibition of in vitro growth by desferrioxamine

C. Raventos-Suarez, S. Pollack, R. L. Nagel

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


Infectious agents must acquire iron from their host to survive, and iron deficiency has been reported to protect against malaria in humans. We have tested the susceptibility of Plasmodium falciparum to iron deprivation by studying the effect of desferrioxamine (DF), a specific iron chelating agent, on parasite growth in an in vitro culture system. We have found that DF inhibits the growth of P. falciparum at concentrations readily achievable in vivo, by a mechanism that may involve interference with the completion of schizogony.

Original languageEnglish (US)
Pages (from-to)919-922
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number5
StatePublished - 1982

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases


Dive into the research topics of 'Plasmodium falciparum: Inhibition of in vitro growth by desferrioxamine'. Together they form a unique fingerprint.

Cite this