TY - JOUR
T1 - Plasma proteomic profile of abdominal obesity in older adults
AU - Sathyan, Sanish
AU - Milman, Sofiya
AU - Ayers, Emmeline
AU - Gao, Tina
AU - Verghese, Joe
AU - Barzilai, Nir
N1 - Publisher Copyright:
© 2024 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
PY - 2024/5
Y1 - 2024/5
N2 - Objective: This study examines the plasma proteomic profile of abdominal obesity in older adults. Methods: The association of abdominal obesity (waist circumference [WC]) with 4265 plasma proteins identified using the SomaScan Assay was examined in 969 Ashkenazi Jewish participants (LonGenity cohort), aged 65 years and older (mean [SD] age 75.7 [6.7] years, 55.4% women), using regression models. Pathway analysis, as well as weighted correlation network analysis, was performed. WC was determined from the proteome using elastic net regression. Results: A total of 480 out of 4265 proteins were associated with WC in the linear regression model. Leptin (β [SE] = 12.363 [0.490]), inhibin β C chain (INHBC; β [SE] = 24.324 [1.448]), insulin-like growth factor-binding protein 2 (IGFBP-2; β [SE] = −12.782 [0.841]), heparan-sulfate 6-O-sulfotransferase 3 (H6ST3; β [SE] = −39.995 [2.729]), and matrix-remodeling-associated protein 8 (MXRA8; β [SE] = −27.101 [1.850]) were the top proteins associated with WC. Cell adhesion, extracellular matrix remodeling, and IGF transport pathways were the top enriched pathways associated with WC. WC signature determined from plasma proteins was highly correlated with measured WC (r = 0.80) and was associated with various metabolic and physical traits. Conclusions: The study unveiled a multifaceted plasma proteomic profile of abdominal obesity in older adults, offering insights into its wide-ranging impact on the proteome. It also elucidated novel proteins, clusters of correlated proteins, and pathways that are intricately associated with abdominal obesity.
AB - Objective: This study examines the plasma proteomic profile of abdominal obesity in older adults. Methods: The association of abdominal obesity (waist circumference [WC]) with 4265 plasma proteins identified using the SomaScan Assay was examined in 969 Ashkenazi Jewish participants (LonGenity cohort), aged 65 years and older (mean [SD] age 75.7 [6.7] years, 55.4% women), using regression models. Pathway analysis, as well as weighted correlation network analysis, was performed. WC was determined from the proteome using elastic net regression. Results: A total of 480 out of 4265 proteins were associated with WC in the linear regression model. Leptin (β [SE] = 12.363 [0.490]), inhibin β C chain (INHBC; β [SE] = 24.324 [1.448]), insulin-like growth factor-binding protein 2 (IGFBP-2; β [SE] = −12.782 [0.841]), heparan-sulfate 6-O-sulfotransferase 3 (H6ST3; β [SE] = −39.995 [2.729]), and matrix-remodeling-associated protein 8 (MXRA8; β [SE] = −27.101 [1.850]) were the top proteins associated with WC. Cell adhesion, extracellular matrix remodeling, and IGF transport pathways were the top enriched pathways associated with WC. WC signature determined from plasma proteins was highly correlated with measured WC (r = 0.80) and was associated with various metabolic and physical traits. Conclusions: The study unveiled a multifaceted plasma proteomic profile of abdominal obesity in older adults, offering insights into its wide-ranging impact on the proteome. It also elucidated novel proteins, clusters of correlated proteins, and pathways that are intricately associated with abdominal obesity.
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U2 - 10.1002/oby.24000
DO - 10.1002/oby.24000
M3 - Article
C2 - 38439214
AN - SCOPUS:85186879595
SN - 1930-7381
VL - 32
SP - 938
EP - 948
JO - Obesity
JF - Obesity
IS - 5
ER -