Planar cell polarity signaling: A common mechanism for cellular polarization

Andreas Jenny, Marek Mlodzik

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Epithelial cells frequently display - in addition to the common apical-basolateral polarity - a polarization within the plane of the epithelium. This is commonly referred to as planar cell polarity (PCP) or tissue polarity. Examples of vertebrate PCP include epithelial patterning in the skin and inner ear, and also the morphogenetic movements of mesenchymal cells during convergent extension at gastrulation. In Drosophila, all adult epithelial structures of the cuticle are polarized within the plane. This review presents recent results and new insights into the molecular mechanisms underlying the establishment of PCP, and compares and contrasts the intriguing similarities between PCP signaling in Drosophila and vertebrates.

Original languageEnglish (US)
Pages (from-to)738-750
Number of pages13
JournalMount Sinai Journal of Medicine
Issue number5
StatePublished - Sep 1 2006
Externally publishedYes


  • Convergent extension
  • Drosophila
  • Frizzled
  • Mouse
  • Organ of Corti
  • Planar cell polarity
  • Tissue polarity
  • Zebrafish

ASJC Scopus subject areas

  • General Medicine


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