TY - JOUR
T1 - Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus
AU - Picardo, Michel Aimé
AU - Guigue, Philippe
AU - Bonifazi, Paolo
AU - Batista-Brito, Renata
AU - Allene, Camille
AU - Ribas, Alain
AU - Fishell, Gord
AU - Baude, Agnès
AU - Cossart, Rosa
N1 - Funding Information:
We thank Dr. R. Machold for generating the Dlx1/2-creER allele and Dr. J. Johnston for providing the Mash1 CreERTM mouse. We thank Drs. Y. Ben-Ari and S. Feldt for critical comments. We thank Dr. M. Esclapez for providing occasional access to her Neurolucida system. Research in the Cossart group was supported by grants from the European Research Council (ERC FP7 Young Investigators 242852), the Fondation pour la Recherche Medicale (Equipe FRM 2008), the Fondation Bettencourt Schueller, INSERM, the Ville de Marseille and Region PACA and the FRC. Drs. R. Cossart and A. Baude are funded by the CNRS. Research in the Fishell laboratory is supported by the National Institutes of Health (RO1 grants R01MH071679 and R01NS039007).
PY - 2011/8/25
Y1 - 2011/8/25
N2 - Connectivity in the developing hippocampus displays a functional organization particularly effective in supporting network synchronization, as it includes superconnected hub neurons. We have previously shown that hub network function is supported by a subpopulation of GABA neurons. However, it is unclear whether hub cells are only transiently present or later develop into distinctive subclasses of interneurons. These questions are difficult to assess given the heterogeneity of the GABA neurons and the poor early expression of markers. To circumvent this conundrum, we used "genetic fate mapping" that allows for the selective labeling of GABA neurons based on their place and time of origin. We show that early-generated GABA cells form a subpopulation of hub neurons, characterized by an exceptionally widespread axonal arborization and the ability to single-handedly impact network dynamics when stimulated. Pioneer hub neurons remain into adulthood, when they acquire the classical markers of long-range projecting GABA neurons. Video Abstract:
AB - Connectivity in the developing hippocampus displays a functional organization particularly effective in supporting network synchronization, as it includes superconnected hub neurons. We have previously shown that hub network function is supported by a subpopulation of GABA neurons. However, it is unclear whether hub cells are only transiently present or later develop into distinctive subclasses of interneurons. These questions are difficult to assess given the heterogeneity of the GABA neurons and the poor early expression of markers. To circumvent this conundrum, we used "genetic fate mapping" that allows for the selective labeling of GABA neurons based on their place and time of origin. We show that early-generated GABA cells form a subpopulation of hub neurons, characterized by an exceptionally widespread axonal arborization and the ability to single-handedly impact network dynamics when stimulated. Pioneer hub neurons remain into adulthood, when they acquire the classical markers of long-range projecting GABA neurons. Video Abstract:
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U2 - 10.1016/j.neuron.2011.06.018
DO - 10.1016/j.neuron.2011.06.018
M3 - Article
C2 - 21867885
AN - SCOPUS:80051882714
SN - 0896-6273
VL - 71
SP - 695
EP - 709
JO - Neuron
JF - Neuron
IS - 4
ER -