TY - JOUR
T1 - Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death
AU - Migliorati, Graziella
AU - D'adamio, Luciano
AU - Coppi, Germano
AU - Nicoletti, Ildo
AU - Riccardi, Carlo
PY - 1992
Y1 - 1992
N2 - Experiments were performed to analyze the possible effect of the immunomodulating agent Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid) on mouse Natural Killer (NK) cell activity and glucocorticoid hormone(GCH)-induced thymocyte apoptosis. The results indicate that in vivo treatment with Pidotimod (200 mg/Kg ip for 5 days) causes a significant increase in NK activity and in vitro treatment produces a significant reduction of dexamethasone-induced thymocyte apoptosis. This inhibition appears to be dose-dependent and is also evident against TPA or Ca+plus;ionophore-induced apoptosis.
AB - Experiments were performed to analyze the possible effect of the immunomodulating agent Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid) on mouse Natural Killer (NK) cell activity and glucocorticoid hormone(GCH)-induced thymocyte apoptosis. The results indicate that in vivo treatment with Pidotimod (200 mg/Kg ip for 5 days) causes a significant increase in NK activity and in vitro treatment produces a significant reduction of dexamethasone-induced thymocyte apoptosis. This inhibition appears to be dose-dependent and is also evident against TPA or Ca+plus;ionophore-induced apoptosis.
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U2 - 10.3109/08923979209009231
DO - 10.3109/08923979209009231
M3 - Article
C2 - 1294620
AN - SCOPUS:0026622003
SN - 0892-3973
VL - 14
SP - 737
EP - 748
JO - Immunopharmacology and Immunotoxicology
JF - Immunopharmacology and Immunotoxicology
IS - 4
ER -