Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death

Graziella Migliorati, Luciano D'adamio, Germano Coppi, Ildo Nicoletti, Carlo Riccardi

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Experiments were performed to analyze the possible effect of the immunomodulating agent Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid) on mouse Natural Killer (NK) cell activity and glucocorticoid hormone(GCH)-induced thymocyte apoptosis. The results indicate that in vivo treatment with Pidotimod (200 mg/Kg ip for 5 days) causes a significant increase in NK activity and in vitro treatment produces a significant reduction of dexamethasone-induced thymocyte apoptosis. This inhibition appears to be dose-dependent and is also evident against TPA or Ca+plus;ionophore-induced apoptosis.

Original languageEnglish (US)
Pages (from-to)737-748
Number of pages12
JournalImmunopharmacology and Immunotoxicology
Issue number4
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology


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