Physiology of Mycobacteria

Gregory M. Cook, Michael Berney, Susanne Gebhard, Matthias Heinemann, Robert A. Cox, Olga Danilchanka, Michael Niederweis

Research output: Chapter in Book/Report/Conference proceedingChapter

129 Scopus citations


Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has achieved a spread in the human population that is unmatched by any other bacterial pathogen. The success of M. tuberculosis as a pathogen can be attributed to its extraordinary stealth and capacity to adapt to environmental changes throughout the course of infection. These changes include: nutrient deprivation, hypoxia, various exogenous stress conditions and, in the case of the pathogenic species, the intraphagosomal environment. Knowledge of the physiology of M. tuberculosis during this process has been limited by the slow growth of the bacterium in the laboratory and other technical problems such as cell aggregation. Advances in genomics and molecular methods to analyze the M. tuberculosis genome have revealed that adaptive changes are mediated by complex regulatory networks and signals, resulting in temporal gene expression coupled to metabolic and energetic changes. An important goal for bacterial physiologists will be to elucidate the physiology of M. tuberculosis during the transition between the diverse conditions encountered by M. tuberculosis. This review covers the growth of the mycobacterial cell and how environmental stimuli are sensed by this bacterium. Adaptation to different environments is described from the viewpoint of nutrient acquisition, energy generation, and regulation. To gain quantitative understanding of mycobacterial physiology will require a systems biology approach and recent efforts in this area are discussed.

Original languageEnglish (US)
Title of host publicationAdvances in Microbial Physiology
PublisherAcademic Press
ISBN (Print)9780123747907
StatePublished - 2009
Externally publishedYes

Publication series

NameAdvances in Microbial Physiology
ISSN (Print)0065-2911

ASJC Scopus subject areas

  • Microbiology
  • Physiology


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