Physiological effects of obstructive sleep apnea syndrome in childhood

Hiren Muzumdar, Raanan Arens

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Sleep disordered breathing in children refers to a group of respiratory disorders that occur or are exacerbated during sleep. Obstructive sleep apnea syndrome (OSAS) is one of the most significant disorders in this group. OSAS can present in all age groups from early infancy to adolescent years. The cardinal feature of OSAS is limitation of inspiratory flow and volume during sleep resulting in abnormal gas exchange and/or alteration of sleep patterns. When OSAS is a chronic condition it often results in adverse physiological effects that impact on health and development. The present review discusses genesis of OSAS in children and consequent end organ injury with special emphasis on behavior and cognition, cardiovascular function, autonomic regulation, inflammation, endothelial function and metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)370-382
Number of pages13
JournalRespiratory Physiology and Neurobiology
Issue number3
StatePublished - Sep 15 2013


  • Children
  • Obstructive sleep apnea
  • Pathophysiology
  • Physiology
  • Sleep disordered breathing

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology
  • Pulmonary and Respiratory Medicine


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