Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases

Rachel Schnur Salamon, Jonathan M. Backer

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Class I PI 3-kinases signal by producing the signaling lipid phosphatidylinositol(3,4,5) trisphosphate, which in turn acts by recruiting downstream effectors that contain specific lipid-binding domains. The class I PI 3-kinases comprise four distinct catalytic subunits linked to one of seven different regulatory subunits. All the class I PI 3-kinases produce the same signaling lipid, PIP3, and the different isoforms have overlapping expression patterns and are coupled to overlapping sets of upstream activators. Nonetheless, studies in cultured cells and in animals have demonstrated that the different isoforms are coupled to distinct ranges of downstream responses. This review focuses on the mechanisms by which the production of a common product, PIP3, can produce isoform-specific signaling by PI 3-kinases.

Original languageEnglish (US)
Pages (from-to)602-611
Number of pages10
Issue number7
StatePublished - Jul 2013


  • PH domain
  • PI 3-kinase
  • Phosphoinositides
  • Signal transduction

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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