Phase II trial of VP-16-213 in non-small-cell lung cancer

L. M. Itri, R. J. Gralla, R. A. Chapman, D. P. Kelsen, E. S. Casper, R. B. Golbey

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Fifty-one patients with metastatic non-small-cell lung cancer (NSCLC) were treated with VP-16-213 (4'-demethylepipodophyllotoxin) during a phase II trial. Of the 49 patients who had adequate trials, 2 patients achieved a partial response (PR), for an overall 4% major response rate. The median Karnofsky performance status (PS) was 80%; 85.7% of patients had adenocarcinoma and 14.2% had epidermoid carcinoma. Prior treatment with chemotherapy may have adversely affected response rate; the two responses occurred among the 25 previously untreated patients, while no responses were seen in patients who had previously received chemotherapy. Myelosuppression was the most frequent side effect and two drug-related deaths due to septicemia occurred. Other toxic effects noted included anorexia, nausea and vomiting, partial alopecia, and, in one patient, chills and hypotension during drug infusion. We conclude that VP-16-213 has minimal activity as a single agent in NSCLC.

Original languageEnglish (US)
Pages (from-to)45-47
Number of pages3
JournalUnknown Journal
Issue number1
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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