TY - JOUR
T1 - Pharmacotherapy of diabetes mellitus
T2 - Implications for the prevention and treatment of cardiovascular disease
AU - Ragucci, Enzo
AU - Zonszein, Joel
AU - Frishman, William H.
PY - 2003
Y1 - 2003
N2 - Diabetes mellitus in adults is associated with an increased risk of premature vascular disease and a higher mortality rate. The presence of other risk factors, often seen in diabetic patients, such as systemic hypertension, augments the rate of vascular diseases. Evidence is growing that tight control of hyperglycemia using insulin and/or oral hypoglycemic agents will modify this risk. More aggressive control of concomitant hypertension and/or hyperlipidemia is also required. Diabetic patients who have myocardial infarctions do worse than nondiabetic patients. Various strategies to improve outcomes include the use of tight blood glucose control, and various coronary interventions are currently under clinical study.
AB - Diabetes mellitus in adults is associated with an increased risk of premature vascular disease and a higher mortality rate. The presence of other risk factors, often seen in diabetic patients, such as systemic hypertension, augments the rate of vascular diseases. Evidence is growing that tight control of hyperglycemia using insulin and/or oral hypoglycemic agents will modify this risk. More aggressive control of concomitant hypertension and/or hyperlipidemia is also required. Diabetic patients who have myocardial infarctions do worse than nondiabetic patients. Various strategies to improve outcomes include the use of tight blood glucose control, and various coronary interventions are currently under clinical study.
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U2 - 10.1097/01.HDX.0000050411.62103.F5
DO - 10.1097/01.HDX.0000050411.62103.F5
M3 - Review article
C2 - 12549986
AN - SCOPUS:0037262249
SN - 1521-737X
VL - 5
SP - 18
EP - 33
JO - Heart Disease
JF - Heart Disease
IS - 1
ER -