pH, EF-1α and the cytoskeleton

Gang Liu, Brian T. Edmonds, John Condeelis

Research output: Contribution to journalComment/debatepeer-review

45 Scopus citations


One of the unexpected cellular components found interacting with the cytoskeleton is elongation factor 1 alpha (EF-1α). How this interaction is regulated is not clear, but pH may be a potent regulator. Interestingly, pH also regulates the amount of protein translation occurring in many cell systems. In this paper, the authors suggest that sequestration of EF-1α in the cytoskeleton may play a key role in regulating the spatial distribution of macromolecular assembly in a way that is dependent on cytoplasmic pH.

Original languageEnglish (US)
Pages (from-to)168-171
Number of pages4
JournalTrends in Cell Biology
Issue number5
StatePublished - May 1996

ASJC Scopus subject areas

  • Cell Biology


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