P‐glycoprotein transports corticosterone and is photoaffinity‐labeled by the steroid

David C. Wolf, Susan Band Horwitz

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Multi‐drug‐resistant cells overproduce a 130–180‐kDa integral membrane phosphoglycoprotein known as P‐glycoprotein which acts as an energy‐dependent drug efflux pump. While P‐glycoprotein has been shown to transport hydrophobic anti tumor drugs out of multi‐drug‐resistant cells in tissue culture, its endogenous substrates remain unknown. This report shows that 3H‐corticosterone can specifically photoaffinity label P‐glycoprotein. Furthermore, corticosterone is effluxed from multidrug‐resistant cells by P‐glycoprotein. These data suggest that corticosterone may be an endogenous substrate for P‐glycoprotein. © 1992 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalInternational Journal of Cancer
Issue number1
StatePublished - Aug 19 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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