TY - JOUR
T1 - Perturbed MAPK signaling in ASD
T2 - Impact of metal neurotoxicity
AU - Aluko, Oritoke M.
AU - Lawal, Saheed A.
AU - Ijomone, Omamuyovwi M.
AU - Aschner, Michael
N1 - Funding Information:
O.M.I. acknowledges the International Brain Research Grants (IBRO) to The Neuro-Lab, Federal University of Technology Akure, Nigeria. M.A. is supported by the National Institute of Health (NIH), USA grants: NIEHS R01 10563 and NIEHS R01 07331.
Funding Information:
O.M.I. acknowledges the International Brain Research Grants (IBRO) to The Neuro-Lab, Federal University of Technology Akure, Nigeria. M.A. is supported by the National Institute of Health (NIH), USA grants: NIEHS R01 10563 and NIEHS R01 07331 .
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/6
Y1 - 2021/6
N2 - The mitogen-activated protein kinase (MAPK) pathways are intracellular signaling pathways necessary for regulating various physiological processes, including neurodevelopment. The developing brain is vulnerable to toxic substances, and metals, such as lead, mercury, nickel, manganese, and others, have been proven to induce disturbances in the MAPK signaling pathway. Since a well-regulated MAPK is necessary for normal neurodevelopment, perturbation of the MAPK pathway results in neurodevelopmental disorders, including autism spectrum disorder (ASD). ASD affects brain parts responsible for communication, cognition, social interaction, and other patterned behaviors. Several studies have addressed the role of metals in the etiopathogenesis of ASD. Here, we briefly review the MAPK signaling pathway and its role in neurodevelopment. Furthermore, we highlight the role of metal toxicity in the development of ASD and how perturbed MAPK signaling may result in ASD.
AB - The mitogen-activated protein kinase (MAPK) pathways are intracellular signaling pathways necessary for regulating various physiological processes, including neurodevelopment. The developing brain is vulnerable to toxic substances, and metals, such as lead, mercury, nickel, manganese, and others, have been proven to induce disturbances in the MAPK signaling pathway. Since a well-regulated MAPK is necessary for normal neurodevelopment, perturbation of the MAPK pathway results in neurodevelopmental disorders, including autism spectrum disorder (ASD). ASD affects brain parts responsible for communication, cognition, social interaction, and other patterned behaviors. Several studies have addressed the role of metals in the etiopathogenesis of ASD. Here, we briefly review the MAPK signaling pathway and its role in neurodevelopment. Furthermore, we highlight the role of metal toxicity in the development of ASD and how perturbed MAPK signaling may result in ASD.
KW - Autism
KW - MAPK
KW - Metal exposure
KW - Neurodevelopment disorder
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U2 - 10.1016/j.cotox.2021.03.009
DO - 10.1016/j.cotox.2021.03.009
M3 - Review article
AN - SCOPUS:85105357186
SN - 2468-2020
VL - 26
SP - 1
EP - 7
JO - Current Opinion in Toxicology
JF - Current Opinion in Toxicology
ER -