Persistence of abnormal global longitudinal strain in women with peripartum cardiomyopathy

Anna E. Bortnick, Claudia Lama von Buchwald, Aliaskar Hasani, Christina Liu, Julia L. Berkowitz, Shayna Vega, Mohammad Hashim Mustehsan, Diana S. Wolfe, Cynthia Taub

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objectives: Data regarding the longitudinal relationship of global longitudinal strain (GLS) and echocardiographic parameters are lacking in peripartum cardiomyopathy (PPCM). We evaluated GLS and its correlation with change (∆) in left ventricular ejection fraction (LVEF). Methods: We retrospectively identified women age ≥16 years hospitalized at Montefiore Medical Center in Bronx, NY from 1999-2015 with International Statistical Classification of Diseases and Related Health Problems, 9th revision codes for PPCM or an occurrence of unexplained heart failure during or up to 5 months postpartum. N = 195 charts were reviewed for inclusion/exclusion criteria, n = 53 patients met criteria for PPCM, and of those, n = 13 had a baseline and follow-up echocardiogram suitable for GLS analysis. Results: Of those eligible for strain analysis, the mean age was 30 ± 6 years, 46.2% identified as Black and 38.5% as Hispanic/Latina. Baseline LVEF was 30 (25, 35)%, GLS was −13.2 (−14, −7.6)%. At a mean follow-up time of 1.2 ± 0.7 years, 11/13 had persistently mild −15.6 (−16.3, −12.7)%, and 2/13 severely abnormal GLS −7.05 (−7.1, −7.0)%. There was no correlation between baseline GLS and ∆LVEF (r =.014, P =.965). Conclusions: Global longitudinal strain is a sensitive method to identify subclinical myocardial dysfunction. In this series of women with PPCM, GLS remained persistently abnormal over time, even if LVEF improved. Future studies should examine the implication of persistently abnormal GLS in PPCM.

Original languageEnglish (US)
Pages (from-to)885-891
Number of pages7
Issue number6
StatePublished - Jun 2021


  • cardiomyopathy
  • echocardiogram
  • heart failure
  • pregnancy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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