Permission to enter cell by shape: Nanodisk vs Nanosphere

Yi Zhang; Samuel Tekobo; Ying Tu; Qunfang Zhou; Xinlong Jin; Sergey A. Dergunov; Eugene Pinkhassik; Bing Yan

doi:10.1021/am300840p

Permission to enter cell by shape: Nanodisk vs Nanosphere

Yi Zhang, Samuel Tekobo, Ying Tu, Qunfang Zhou, Xinlong Jin, Sergey A. Dergunov, Eugene Pinkhassik, Bing Yan

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.

Original language	English (US)
Pages (from-to)	4099-4105
Number of pages	7
Journal	ACS Applied Materials and Interfaces
Volume	4
Issue number	8
DOIs	https://doi.org/10.1021/am300840p
State	Published - Aug 22 2012
Externally published	Yes

Keywords

cell uptake
cytotoxicity
membrane permeability
nanodisk

ASJC Scopus subject areas

Materials Science(all)

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10.1021/am300840p

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title = "Permission to enter cell by shape: Nanodisk vs Nanosphere",

abstract = "Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.",

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author = "Yi Zhang and Samuel Tekobo and Ying Tu and Qunfang Zhou and Xinlong Jin and Dergunov, {Sergey A.} and Eugene Pinkhassik and Bing Yan",

year = "2012",

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T2 - Nanodisk vs Nanosphere

AU - Zhang, Yi

AU - Tekobo, Samuel

AU - Tu, Ying

AU - Zhou, Qunfang

AU - Jin, Xinlong

AU - Dergunov, Sergey A.

AU - Pinkhassik, Eugene

AU - Yan, Bing

PY - 2012/8/22

Y1 - 2012/8/22

N2 - Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.

AB - Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.

KW - cell uptake

KW - cytotoxicity

KW - membrane permeability

KW - nanodisk

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Permission to enter cell by shape: Nanodisk vs Nanosphere

Abstract

Keywords

ASJC Scopus subject areas

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