Peripheral oxidative stress in relapsing-remitting multiple sclerosis

Inmaculada Tasset, Eduardo Agüera, Fernando Sánchez-López, Montserrat Feijóo, Ana I. Giraldo, Antonio H. Cruz, Félix Gascón, Isaac Túnez

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Objectives: To evaluate levels of oxidative stress in blood samples in patients with relapsing-remitting MS (RR-MS). Design and methods: Peripheral blood samples were collected from 24 RR-MS patients and 15 healthy controls. Levels of the following were measured: carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-S-transferase (GST), myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), serum vascular cell adhesion molecule-1 (sVCAM-1) and serum inter-cellular adhesion molecule 1 (sICAM-1). Results: Values for carbonylated proteins, 8OHdG, total glutathione, GSH, GSH/GSSG ratio, SOD, GRd and GOS were significantly higher in RR-MS patients than in healthy controls. By contrast, PAO, GSSG, GPx and GST were lower in RR-MS patients. Conclusion: Oxidative stress plays a major role in MS, and is observed prior to relapse.

Original languageEnglish (US)
Pages (from-to)440-444
Number of pages5
JournalClinical Biochemistry
Issue number6
StatePublished - Apr 2012
Externally publishedYes


  • Antioxidant system
  • Global oxidative stress
  • Glutathione redox system
  • Multiple sclerosis
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Biochemistry


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