Abstract
Protein tyrosine binding (PTB) and 'post synaptic density disc-large zo-1' (PDZ) domains bind to short peptidic ligands by augmentation of one of the domain's β sheets and other recognition mechanisms. The two domain classes have a superficial resemblance to each other, even though no sequential homology exists. The structural bases of the interactions are well understood for the few domains now experimentally determined, and ligand-target pairs can probably be identified in favorable cases by analogy with the known domains. For both PTB and PDZ classes, functional activities are still not fully defined: it is possible that these domain classes, along with pleckstrin homology domains, have multiple roles.
Original language | English (US) |
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Pages (from-to) | 835-838 |
Number of pages | 4 |
Journal | Current Opinion in Structural Biology |
Volume | 7 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology