TY - JOUR
T1 - Pediatric Nonalcoholic Fatty Liver Disease in New York City
T2 - An Autopsy Study
AU - Fernandes, Danielle M.
AU - Pantangi, Vivek
AU - Azam, Muhammad
AU - Salomao, Marcela
AU - Iuga, Alina C.
AU - Lefkowitch, Jay H.
AU - Gill, James
AU - Morotti, Raffaella
AU - Lavine, Joel E.
AU - Mencin, Ali A.
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/9
Y1 - 2018/9
N2 - Objective: To assess the prevalence and severity of nonalcoholic liver disease (NAFLD) in children in a diverse population sample in New York City. Study design: Liver specimens were examined from children 2-19 years old who died of unexpected causes within 48 hours of medical presentation and underwent autopsy in New York City from 2005 to 2010. Records were reviewed for age, sex, weight, height, and race. Two hepatopathologists evaluated each liver specimen to determine pathologic diagnosis. Results: The final study cohort (n = 582) was 50% black, 33% Hispanic, 12% white, 3% Asian, and 2% other; 36% had a body mass index >85%. There were 26 cases of NAFLD (4.5%) of which 10 had nonalcoholic steatohepatitis (1.7%). There were no cases with severe fibrosis or cirrhosis. One percent (3/290) of black children had NAFLD and none had nonalcoholic steatohepatitis. White and Hispanic children had the highest percentages of NAFLD at 8.3% and 7.9%, respectively. In multiple logistic regression models, we observed that body mass index z-score (P <.001) was associated with NAFLD, and that white (P =.003) and Hispanic (P =.005) children had higher odds of having NAFLD compared with black children. Conclusions: This review of liver tissue demonstrates a lower prevalence and severity of NAFLD in black children compared with the general obese pediatric population. Hispanic children did not have a significantly increased rate of NAFLD compared with white children, most likely related to the large proportion of Caribbean Hispanic children in New York City.
AB - Objective: To assess the prevalence and severity of nonalcoholic liver disease (NAFLD) in children in a diverse population sample in New York City. Study design: Liver specimens were examined from children 2-19 years old who died of unexpected causes within 48 hours of medical presentation and underwent autopsy in New York City from 2005 to 2010. Records were reviewed for age, sex, weight, height, and race. Two hepatopathologists evaluated each liver specimen to determine pathologic diagnosis. Results: The final study cohort (n = 582) was 50% black, 33% Hispanic, 12% white, 3% Asian, and 2% other; 36% had a body mass index >85%. There were 26 cases of NAFLD (4.5%) of which 10 had nonalcoholic steatohepatitis (1.7%). There were no cases with severe fibrosis or cirrhosis. One percent (3/290) of black children had NAFLD and none had nonalcoholic steatohepatitis. White and Hispanic children had the highest percentages of NAFLD at 8.3% and 7.9%, respectively. In multiple logistic regression models, we observed that body mass index z-score (P <.001) was associated with NAFLD, and that white (P =.003) and Hispanic (P =.005) children had higher odds of having NAFLD compared with black children. Conclusions: This review of liver tissue demonstrates a lower prevalence and severity of NAFLD in black children compared with the general obese pediatric population. Hispanic children did not have a significantly increased rate of NAFLD compared with white children, most likely related to the large proportion of Caribbean Hispanic children in New York City.
KW - hepatic transaminases
KW - nonalcoholic steatohepatitis
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U2 - 10.1016/j.jpeds.2018.04.047
DO - 10.1016/j.jpeds.2018.04.047
M3 - Article
C2 - 29903531
AN - SCOPUS:85048221397
SN - 0022-3476
VL - 200
SP - 174
EP - 180
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -