TY - JOUR
T1 - Pediatric Intensive Care Unit Patients
T2 - Sedation, Monitoring, and Neurodevelopmental Outcomes
AU - Lee, Jennifer J.
AU - Jaconia, Giselle D.
AU - Sun, Lena S.
AU - Biagas, Katherine V.
AU - Naim, Maryam Y.
AU - Beers, Sue R.
AU - Mintz, C. David
AU - Smith, Heidi A.B.
N1 - Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - The design and conduct of pediatric sedation studies in critically ill patients have historically been challenging due to the complexity of the pediatric intensive care unit (PICU) environment and the difficulty of establishing equipoise. Clinical trials, for instance, represent 1 important means of advancing our knowledge in this field, but there is a paucity of such studies in the literature. Accounting for ground-level factors in planning for each trial phase (eg, enrollment, intervention, assessment, and follow-up) and the presence of broader system limitations is of key importance. In addition, there is a need for early planning, coordination, and obtaining buy-in from individual study sites and staff to ensure success, particularly for multicenter studies. This review synthesizes the current state of pediatric sedation research and the myriad of challenges in designing and conducting successful trials in this particular area. The review poses consideration for future research directions, including novel study designs, and discusses electroencephalography monitoring and neurodevelopmental outcomes of PICU survivors.
AB - The design and conduct of pediatric sedation studies in critically ill patients have historically been challenging due to the complexity of the pediatric intensive care unit (PICU) environment and the difficulty of establishing equipoise. Clinical trials, for instance, represent 1 important means of advancing our knowledge in this field, but there is a paucity of such studies in the literature. Accounting for ground-level factors in planning for each trial phase (eg, enrollment, intervention, assessment, and follow-up) and the presence of broader system limitations is of key importance. In addition, there is a need for early planning, coordination, and obtaining buy-in from individual study sites and staff to ensure success, particularly for multicenter studies. This review synthesizes the current state of pediatric sedation research and the myriad of challenges in designing and conducting successful trials in this particular area. The review poses consideration for future research directions, including novel study designs, and discusses electroencephalography monitoring and neurodevelopmental outcomes of PICU survivors.
KW - child development
KW - critical care outcomes
KW - electroencephalography
KW - hypnotics and sedatives
KW - intensive care units
KW - neuropsychological tests
KW - pediatric
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U2 - 10.1097/ANA.0000000000000881
DO - 10.1097/ANA.0000000000000881
M3 - Article
C2 - 36745180
AN - SCOPUS:85143586039
SN - 0898-4921
VL - 35
SP - 147
EP - 152
JO - Journal of Neurosurgical Anesthesiology
JF - Journal of Neurosurgical Anesthesiology
IS - 1
ER -