Pathophysiology of focal segmental glomerulosclerosis

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63 Scopus citations


Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal models and studies of familial forms of nephrotic syndrome helped elucidate some mechanisms of podocyte injury and disease progression in FSGS. This article reviews some of the experimental and clinical data on the pathophysiology of FSGS.

Original languageEnglish (US)
Pages (from-to)350-354
Number of pages5
JournalPediatric Nephrology
Issue number3
StatePublished - Mar 2007


  • Animal models
  • Focal segmental glomerulosclerosis (FSGS)
  • Injury
  • Nephrin
  • Nephrotics yndrome
  • Pathophysiology
  • Podocin
  • Podocyte
  • Transforming growth factor (TGFβ)
  • Tubulointerstitial

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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