Pathophysiology of chaperone-mediated autophagy

Ashish Massey, Roberta Kiffin, Ana Maria Cuervo

Research output: Contribution to journalReview articlepeer-review

158 Scopus citations


In contrast to the classically described "in bulk" lysosomal degradation, the first evidence for selective degradation of cytosolic proteins in lysosomes was presented more than 20 years ago. Throughout this time, we have gained a better understanding about this process, now known as chaperone-mediated autophagy (CMA). The identification of new substrates for CMA and novel components, in both the cytosol and the lysosomes, along with better insights on how CMA is regulated, have all helped to shape the possible physiological roles of CMA. We review here different intracellular functions of CMA that arise from its unique characteristics when compared to other forms of autophagy. In view of these functions, we discuss the relevance of the changes in CMA activity in aging and in different pathological conditions.

Original languageEnglish (US)
Pages (from-to)2420-2434
Number of pages15
JournalInternational Journal of Biochemistry and Cell Biology
Issue number12
StatePublished - Dec 2004


  • Aging
  • Lysosomal storage disorders
  • Lysosomes
  • Nephropathy
  • Neurodegeneration

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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