Pathophysiology, assessment and management of the child with growth hormone resistance

M. O. Savage, L. Cohen, A. J. Cohen, P. Cohen, P. H. Saenger

Research output: Contribution to journalArticlepeer-review


Defects in the growth hormone (GH)-insulin-like growth factor (IGF)-I axis may cause GH resistance characterized by IGF-I deficiency and growth failure. The range of defects causing GH resistance is broad as are their biochemical and phenotypical characteristics. We propose that GH-IGF-I axis defects form a continuum of clinical and biochemical effects ranging from GH deficiency to GH resistance. The pathophysiology of GH resistance is described followed by a scheme for investigation of the child with severe short stature and normal GH secretion. We critically discuss GH therapy for such patients and define acceptable growth responsiveness. Finally we discuss therapy with IGF-I within the limits of the USA Food and Drug Administration and European Medicines Agency labels for GH resistance.

Original languageEnglish (US)
Pages (from-to)347-356
Number of pages10
JournalPediatric Endocrinology Reviews
Issue number4
StatePublished - Jun 2010
Externally publishedYes


  • GH resistance
  • Growth
  • Growth hormone
  • IGF-I
  • IGF-I therapy
  • Laron syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism


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