Pathophysiologic basis for the medical management of portal hypertension

Fred F. Poordad; Samuel H. Sigal; Robert S. Brown

doi:10.1517/14656560802707853

Pathophysiologic basis for the medical management of portal hypertension

Fred F. Poordad, Samuel H. Sigal, Robert S. Brown

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Background: Portal hypertension is a potentially life-threatening complication of cirrhosis, resulting from increased intrahepatic resistance and portal inflow. Objective: Given the complex nature of this disorder, a more complete understanding of the pathophysiology of portal hypertension is necessary to develop new therapies that target specific pathways that regulate portal pressure. Methods: This review is based on a literature search of published articles and abstracts on the pathophysiology of portal hypertension, its complications and its treatment. Results/conclusion: A number of therapies have been developed or are under investigation for the treatment of portal hypertension and its complications. These agents may reduce mortality and improve quality of life for patients with advanced liver disease.

Original language	English (US)
Pages (from-to)	453-467
Number of pages	15
Journal	Expert Opinion on Pharmacotherapy
Volume	10
Issue number	3
DOIs	https://doi.org/10.1517/14656560802707853
State	Published - Feb 2009
Externally published	Yes

Keywords

Ascites
Cirrhosis
Fibrosis
Hepatic encephalopathy
Hepatology
Hepatorenal syndrome
Liver
Portal hypertension
Portal vein
Variceal bleeding
Varices

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

Access to Document

10.1517/14656560802707853

Cite this

@article{e29f64279a61462d978d35ebdf180084,

title = "Pathophysiologic basis for the medical management of portal hypertension",

abstract = "Background: Portal hypertension is a potentially life-threatening complication of cirrhosis, resulting from increased intrahepatic resistance and portal inflow. Objective: Given the complex nature of this disorder, a more complete understanding of the pathophysiology of portal hypertension is necessary to develop new therapies that target specific pathways that regulate portal pressure. Methods: This review is based on a literature search of published articles and abstracts on the pathophysiology of portal hypertension, its complications and its treatment. Results/conclusion: A number of therapies have been developed or are under investigation for the treatment of portal hypertension and its complications. These agents may reduce mortality and improve quality of life for patients with advanced liver disease.",

keywords = "Ascites, Cirrhosis, Fibrosis, Hepatic encephalopathy, Hepatology, Hepatorenal syndrome, Liver, Portal hypertension, Portal vein, Variceal bleeding, Varices",

author = "Poordad, {Fred F.} and Sigal, {Samuel H.} and Brown, {Robert S.}",

note = "Funding Information: The manuscript was supported by GlaxoSmithKline. All the authors have received grant support from Salix.",

year = "2009",

month = feb,

doi = "10.1517/14656560802707853",

language = "English (US)",

volume = "10",

pages = "453--467",

journal = "Expert Opinion on Pharmacotherapy",

issn = "1465-6566",

publisher = "Informa Healthcare",

number = "3",

}

TY - JOUR

T1 - Pathophysiologic basis for the medical management of portal hypertension

AU - Poordad, Fred F.

AU - Sigal, Samuel H.

AU - Brown, Robert S.

N1 - Funding Information: The manuscript was supported by GlaxoSmithKline. All the authors have received grant support from Salix.

PY - 2009/2

Y1 - 2009/2

N2 - Background: Portal hypertension is a potentially life-threatening complication of cirrhosis, resulting from increased intrahepatic resistance and portal inflow. Objective: Given the complex nature of this disorder, a more complete understanding of the pathophysiology of portal hypertension is necessary to develop new therapies that target specific pathways that regulate portal pressure. Methods: This review is based on a literature search of published articles and abstracts on the pathophysiology of portal hypertension, its complications and its treatment. Results/conclusion: A number of therapies have been developed or are under investigation for the treatment of portal hypertension and its complications. These agents may reduce mortality and improve quality of life for patients with advanced liver disease.

AB - Background: Portal hypertension is a potentially life-threatening complication of cirrhosis, resulting from increased intrahepatic resistance and portal inflow. Objective: Given the complex nature of this disorder, a more complete understanding of the pathophysiology of portal hypertension is necessary to develop new therapies that target specific pathways that regulate portal pressure. Methods: This review is based on a literature search of published articles and abstracts on the pathophysiology of portal hypertension, its complications and its treatment. Results/conclusion: A number of therapies have been developed or are under investigation for the treatment of portal hypertension and its complications. These agents may reduce mortality and improve quality of life for patients with advanced liver disease.

KW - Ascites

KW - Cirrhosis

KW - Fibrosis

KW - Hepatic encephalopathy

KW - Hepatology

KW - Hepatorenal syndrome

KW - Liver

KW - Portal hypertension

KW - Portal vein

KW - Variceal bleeding

KW - Varices

UR - http://www.scopus.com/inward/record.url?scp=65649104408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65649104408&partnerID=8YFLogxK

U2 - 10.1517/14656560802707853

DO - 10.1517/14656560802707853

M3 - Review article

C2 - 19191681

AN - SCOPUS:65649104408

SN - 1465-6566

VL - 10

SP - 453

EP - 467

JO - Expert Opinion on Pharmacotherapy

JF - Expert Opinion on Pharmacotherapy

IS - 3

ER -

Pathophysiologic basis for the medical management of portal hypertension

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this