TY - JOUR
T1 - Pathogens hijack the epigenome
T2 - A new twist on host-pathogen interactions
AU - Silmon De Monerri, Natalie C.
AU - Kim, Kami
N1 - Funding Information:
Supported by NIH grants R01AI087625 and RC4AI092801 (K.K.) and Einstein-Montefiore Center for AIDS Research grant P30AI051519 .
PY - 2014/4
Y1 - 2014/4
N2 - Pathogens have evolved strategies to promote their survival by dramatically modifying the transcriptional profile and protein content of the host cells they infect. Modifications of the host transcriptome and proteome are mediated by pathogen-encoded effector molecules that modulate host cells through a variety of different mechanisms. Recent studies highlight the importance of the host chromatin and other epigenetic regulators as targets of pathogens. Host gene regulatory mechanisms may be targeted through cytoplasmic signaling, directly by pathogen effector proteins, and possibly by pathogen RNA. Although many of these changes are short-lived and persist only during the course of infection, several studies indicate that pathogens are able to induce long-term, heritable changes that are essential to pathogenesis of infectious diseases and persistence of pathogens within their hosts. In this review, we discuss how pathogens modulate the epigenome of host cells, a new and flourishing avenue of host-pathogen interaction studies.
AB - Pathogens have evolved strategies to promote their survival by dramatically modifying the transcriptional profile and protein content of the host cells they infect. Modifications of the host transcriptome and proteome are mediated by pathogen-encoded effector molecules that modulate host cells through a variety of different mechanisms. Recent studies highlight the importance of the host chromatin and other epigenetic regulators as targets of pathogens. Host gene regulatory mechanisms may be targeted through cytoplasmic signaling, directly by pathogen effector proteins, and possibly by pathogen RNA. Although many of these changes are short-lived and persist only during the course of infection, several studies indicate that pathogens are able to induce long-term, heritable changes that are essential to pathogenesis of infectious diseases and persistence of pathogens within their hosts. In this review, we discuss how pathogens modulate the epigenome of host cells, a new and flourishing avenue of host-pathogen interaction studies.
UR - http://www.scopus.com/inward/record.url?scp=84897850450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897850450&partnerID=8YFLogxK
U2 - 10.1016/j.ajpath.2013.12.022
DO - 10.1016/j.ajpath.2013.12.022
M3 - Review article
C2 - 24525150
AN - SCOPUS:84897850450
SN - 0002-9440
VL - 184
SP - 897
EP - 911
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 4
ER -