Palladium-catalyzed amidation of 2-chloropyrimidines

Marc Vimolratana, Jillian L. Simard, Sean P. Brown

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1.

Original languageEnglish (US)
Pages (from-to)1020-1022
Number of pages3
JournalTetrahedron Letters
Issue number9
StatePublished - Mar 2 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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