Palladium-catalyzed amidation of 2-chloropyrimidines

Marc Vimolratana; Jillian L. Simard; Sean P. Brown

doi:10.1016/j.tetlet.2010.12.088

Palladium-catalyzed amidation of 2-chloropyrimidines

Marc Vimolratana, Jillian L. Simard, Sean P. Brown

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1.

Original language	English (US)
Pages (from-to)	1020-1022
Number of pages	3
Journal	Tetrahedron Letters
Volume	52
Issue number	9
DOIs	https://doi.org/10.1016/j.tetlet.2010.12.088
State	Published - Mar 2 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2010.12.088

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title = "Palladium-catalyzed amidation of 2-chloropyrimidines",

abstract = "A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1.",

author = "Marc Vimolratana and Simard, {Jillian L.} and Brown, {Sean P.}",

year = "2011",

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doi = "10.1016/j.tetlet.2010.12.088",

language = "English (US)",

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AU - Vimolratana, Marc

AU - Simard, Jillian L.

AU - Brown, Sean P.

PY - 2011/3/2

Y1 - 2011/3/2

N2 - A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1.

AB - A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1.

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DO - 10.1016/j.tetlet.2010.12.088

M3 - Article

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EP - 1022

JO - Tetrahedron Letters

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ER -

Palladium-catalyzed amidation of 2-chloropyrimidines

Abstract

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