Oxytocin deficiency impairs maternal skeletal remodeling

Xuan Liu; Kengo Shimono; Ling Ling Zhu; Jianhua Li; Yuanzhen Peng; Aliza Imam; Jameel Iqbal; Surinder Moonga; Graziana Colaianni; Cai Su; Zuhong Lu; Masahiro Iwamoto; Maurizio Pacifici; Alberta Zallone; Li Sun; Mone Zaidi

doi:10.1016/j.bbrc.2009.07.148

Oxytocin deficiency impairs maternal skeletal remodeling

Xuan Liu, Kengo Shimono, Ling Ling Zhu, Jianhua Li, Yuanzhen Peng, Aliza Imam, Jameel Iqbal, Surinder Moonga, Graziana Colaianni, Cai Su, Zuhong Lu, Masahiro Iwamoto, Maurizio Pacifici, Alberta Zallone, Li Sun, Mone Zaidi

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

We have reported that the posterior pituitary hormone, oxytocin (OT), known for its effects in inducing parturition, lactation and social bonding, is also a skeletal hormone. Here, we demonstrate that OT plays a key role in enabling maternal skeletal mobilization during pregnancy by enhancing the formation of bone resorbing osteoclasts. Osteoclast formation ex vivo is thus diminished in pregnant mothers with genetic OT-deficiency. OT^-/- pups at day E20 also show a defect in trabecular bone. μCT measurements reveal normal bone volume, but increased trabecular numbers, suggesting that trabeculae in OT^-/- pups are hypomineralized. We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups.

Original language	English (US)
Pages (from-to)	161-166
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	388
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2009.07.148
State	Published - Oct 9 2009
Externally published	Yes

Keywords

Bone density
Osteoblast
Osteoclast
Pituitary hormones

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2009.07.148

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title = "Oxytocin deficiency impairs maternal skeletal remodeling",

abstract = "We have reported that the posterior pituitary hormone, oxytocin (OT), known for its effects in inducing parturition, lactation and social bonding, is also a skeletal hormone. Here, we demonstrate that OT plays a key role in enabling maternal skeletal mobilization during pregnancy by enhancing the formation of bone resorbing osteoclasts. Osteoclast formation ex vivo is thus diminished in pregnant mothers with genetic OT-deficiency. OT-/- pups at day E20 also show a defect in trabecular bone. μCT measurements reveal normal bone volume, but increased trabecular numbers, suggesting that trabeculae in OT-/- pups are hypomineralized. We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups.",

keywords = "Bone density, Osteoblast, Osteoclast, Pituitary hormones",

author = "Xuan Liu and Kengo Shimono and Zhu, {Ling Ling} and Jianhua Li and Yuanzhen Peng and Aliza Imam and Jameel Iqbal and Surinder Moonga and Graziana Colaianni and Cai Su and Zuhong Lu and Masahiro Iwamoto and Maurizio Pacifici and Alberta Zallone and Li Sun and Mone Zaidi",

note = "Funding Information: M.Z. and S.L. acknowledge the National Institutes of Health for support (AG 23176, DK70526 and DK80459). X.L. is a graduate student sponsored by State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China. J.I. acknowledges the support of the American Federation for Aging Research.",

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doi = "10.1016/j.bbrc.2009.07.148",

language = "English (US)",

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T1 - Oxytocin deficiency impairs maternal skeletal remodeling

AU - Liu, Xuan

AU - Shimono, Kengo

AU - Zhu, Ling Ling

AU - Li, Jianhua

AU - Peng, Yuanzhen

AU - Imam, Aliza

AU - Iqbal, Jameel

AU - Moonga, Surinder

AU - Colaianni, Graziana

AU - Su, Cai

AU - Lu, Zuhong

AU - Iwamoto, Masahiro

AU - Pacifici, Maurizio

AU - Zallone, Alberta

AU - Sun, Li

AU - Zaidi, Mone

N1 - Funding Information: M.Z. and S.L. acknowledge the National Institutes of Health for support (AG 23176, DK70526 and DK80459). X.L. is a graduate student sponsored by State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China. J.I. acknowledges the support of the American Federation for Aging Research.

PY - 2009/10/9

Y1 - 2009/10/9

N2 - We have reported that the posterior pituitary hormone, oxytocin (OT), known for its effects in inducing parturition, lactation and social bonding, is also a skeletal hormone. Here, we demonstrate that OT plays a key role in enabling maternal skeletal mobilization during pregnancy by enhancing the formation of bone resorbing osteoclasts. Osteoclast formation ex vivo is thus diminished in pregnant mothers with genetic OT-deficiency. OT-/- pups at day E20 also show a defect in trabecular bone. μCT measurements reveal normal bone volume, but increased trabecular numbers, suggesting that trabeculae in OT-/- pups are hypomineralized. We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups.

AB - We have reported that the posterior pituitary hormone, oxytocin (OT), known for its effects in inducing parturition, lactation and social bonding, is also a skeletal hormone. Here, we demonstrate that OT plays a key role in enabling maternal skeletal mobilization during pregnancy by enhancing the formation of bone resorbing osteoclasts. Osteoclast formation ex vivo is thus diminished in pregnant mothers with genetic OT-deficiency. OT-/- pups at day E20 also show a defect in trabecular bone. μCT measurements reveal normal bone volume, but increased trabecular numbers, suggesting that trabeculae in OT-/- pups are hypomineralized. We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups.

KW - Bone density

KW - Osteoblast

KW - Osteoclast

KW - Pituitary hormones

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Oxytocin deficiency impairs maternal skeletal remodeling

Abstract

Keywords

ASJC Scopus subject areas

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