Ovarian Sertoli-Leydig cell tumour with raised serum alpha fetoprotein - A case report

Andrew Tiltman, Katrien Dehaeck, Robbert Soeters, Gary Goldberg, Wilf Levin

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9 Scopus citations


A case of ovarian Sertoli-Leydig cell tumour with a raised serum alpha fetoprotein in reported. The patient first presented at the age of 27 years with a history of 6 years' amenorrhoea followed by 3 months irregular vaginal bleeding. A ovarian tumour was found and excised and shown microscopically to be a spindle cell malignant tumour. The patient was treated with chemotherapy and had a complete response. Thirty months after first presentation there was a recurrence in the pelvis which microscopically showed the typical features of a Sertoli-Leydig cell tumour. Six months later a second recurrence had the microscopic appearance of a lipid cell tumour. A raised serum alpha fetoprotein was found at the time of the second recurrence and immunohistochemistry showed this protein in the Leydig and luteinized cells of the recurrent tumours but not in the spindle cells of the original ovarian neoplasm.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Issue number2
StatePublished - Mar 1987


  • Alpha fetoprotein
  • Ovarian neoplasms
  • Sertoli-Leydig

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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