Outwitting evolution: Fighting drug-resistant TB, Malaria, and HIV

Daniel E. Goldberg, Robert F. Siliciano, William R. Jacobs

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations


Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has been very slow for tuberculosis and malaria and rapid for HIV-1. But for each disease, resistance to most drugs has appeared quickly after the introduction of the drug. Learning how to manage and prevent resistance is a major medical challenge that requires an understanding of the evolutionary dynamics of each pathogen. This Review summarizes the similarities and differences in the evolution of drug resistance for these three pathogens.

Original languageEnglish (US)
Pages (from-to)1271-1283
Number of pages13
Issue number6
StatePublished - Mar 16 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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