TY - JOUR
T1 - Outcomes of patients with end-stage kidney disease hospitalized with COVID-19
AU - Ng, Jia H.
AU - Hirsch, Jamie S.
AU - Wanchoo, Rimda
AU - Sachdeva, Mala
AU - Sakhiya, Vipulbhai
AU - Hong, Susana
AU - Jhaveri, Kenar D.
AU - Fishbane, Steven
AU - Abate, Mersema
AU - Andrade, Hugo Paz
AU - Barnett, Richard L.
AU - Bellucci, Alessandro
AU - Bhaskaran, Madhu C.
AU - Corona, Antonio G.
AU - Flores Chang, Bessy Suyin
AU - Finger, Mark
AU - Gitman, Michael
AU - Halinski, Candice
AU - Hasan, Shamir
AU - Hazzan, Azzour D.
AU - Khanin, Yuriy
AU - Kuan, Aireen
AU - Madireddy, Varun
AU - Malieckal, Deepa
AU - Muzib, Abdulrahman
AU - Nair, Gayatri
AU - Ng, Jia Hwei
AU - Parikh, Rushang
AU - Ross, Daniel W.
AU - Schwarz, Richard
AU - Shah, Hitesh H.
AU - Sharma, Purva
AU - Singhal, Pravin C.
AU - Uppal, Nupur N.
AU - Nair, Vinay V.
N1 - Publisher Copyright:
© 2020 International Society of Nephrology
PY - 2020/12
Y1 - 2020/12
N2 - Given the high risk of infection-related mortality, patients with end-stage kidney disease (ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of patients with and without ESKD, hospitalized with COVID-19. This was a retrospective study of patients admitted with COVID-19 from 13 New York hospitals from March 1, 2020, to April 27, 2020, and followed through May 27, 2020. We measured primary outcome (in-hospital death), and secondary outcomes (mechanical ventilation and length of stay). Of 10,482 patients with COVID-19, 419 had ESKD. Patients with ESKD were older, had a greater percentage self-identified as Black, and more comorbid conditions. Patients with ESKD had a higher rate of in-hospital death than those without (31.7% vs 25.4%, odds ratio 1.38, 95% confidence interval 1.12 - 1.70). This increase rate remained after adjusting for demographic and comorbid conditions (adjusted odds ratio 1.37, 1.09 - 1.73). The odds of length of stay of seven or more days was higher in the group with compared to the group without ESKD in both the crude and adjusted analysis (1.62, 1.27 - 2.06; vs 1.57, 1.22 - 2.02, respectively). There was no difference in the odds of mechanical ventilation between the groups. Independent risk factors for in-hospital death for patients with ESKD were increased age, being on a ventilator, lymphopenia, blood urea nitrogen and serum ferritin. Black race was associated with a lower risk of death. Thus, among patients hospitalized with COVID-19, those with ESKD had a higher rate of in-hospital death compared to those without ESKD.
AB - Given the high risk of infection-related mortality, patients with end-stage kidney disease (ESKD) may be at increased risk with COVID-19. To assess this, we compared outcomes of patients with and without ESKD, hospitalized with COVID-19. This was a retrospective study of patients admitted with COVID-19 from 13 New York hospitals from March 1, 2020, to April 27, 2020, and followed through May 27, 2020. We measured primary outcome (in-hospital death), and secondary outcomes (mechanical ventilation and length of stay). Of 10,482 patients with COVID-19, 419 had ESKD. Patients with ESKD were older, had a greater percentage self-identified as Black, and more comorbid conditions. Patients with ESKD had a higher rate of in-hospital death than those without (31.7% vs 25.4%, odds ratio 1.38, 95% confidence interval 1.12 - 1.70). This increase rate remained after adjusting for demographic and comorbid conditions (adjusted odds ratio 1.37, 1.09 - 1.73). The odds of length of stay of seven or more days was higher in the group with compared to the group without ESKD in both the crude and adjusted analysis (1.62, 1.27 - 2.06; vs 1.57, 1.22 - 2.02, respectively). There was no difference in the odds of mechanical ventilation between the groups. Independent risk factors for in-hospital death for patients with ESKD were increased age, being on a ventilator, lymphopenia, blood urea nitrogen and serum ferritin. Black race was associated with a lower risk of death. Thus, among patients hospitalized with COVID-19, those with ESKD had a higher rate of in-hospital death compared to those without ESKD.
KW - COVID-19
KW - ESKD
KW - ESRD
KW - dialysis
KW - hemodialysis
KW - peritoneal dialysis
UR - http://www.scopus.com/inward/record.url?scp=85094218861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094218861&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2020.07.030
DO - 10.1016/j.kint.2020.07.030
M3 - Article
C2 - 32810523
AN - SCOPUS:85094218861
SN - 0085-2538
VL - 98
SP - 1530
EP - 1539
JO - Kidney international
JF - Kidney international
IS - 6
ER -